Here is the link for the info on Tramadol (from Babby):
[url=http://www.drugs.com/disease-interactions/tramadol,genrx- tramadol.html]http://www.drugs.com/disease-interactions/tramadol,genrx- tramadol.html[/url]
Tramadol (Includes GenRx Tramadol) ↔ Intracranial Pressure
Moderate Potential Hazard, Moderate plausibility
Applies to: Head Injury, Intracranial Hypertension
Tramadol may induce pupillary changes (miosis) that may obscure the existence, extent, or course of intracranial pathology. Therapy with tramadol should be administered cautiously in patients with increased intracranial pressure or head injury. Clinicians should maintain a high index of suspicion for adverse drug reaction when evaluating altered mental status in these patients if they are treated with tramadol.